ZBrush is a professional digital sculpting and 3D modeling software that uses a proprietary "pixol" technology to simulate the experience of working with traditional sculpting materials like clay. It is renowned for its ability to create highly detailed, complex organic models (like characters, creatures, and organic environments) with millions or even billions of polygons.
Think of ZBrush as "digital clay." Instead of shaping a physical block of clay with your hands and tools, you use a graphics tablet and pen to push, pull, carve, and mold a 3D model on your computer screen. It's the industry standard for high-resolution sculpting in film, video games, animation, and collectible design.
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Think of iClone as a "real-time digital movie studio." It provides a complete toolkit—actors, sets, props, cameras, and lights—that you can drag, drop, and manipulate to quickly produce animated scenes. It's known for its ease of use and speed, allowing for rapid prototyping and production of high-quality animation without the need for frame-by-frame manual work or complex coding.